Detalhe da pesquisa
1.
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22.
PLoS Pathog
; 18(1): e1010200, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35025968
2.
Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study.
Allergy
; 79(4): 924-936, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37984453
3.
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy.
J Med Chem
; 65(19): 12895-12924, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36127295
4.
Discovery of a novel potent GABA(B) receptor agonist.
Bioorg Med Chem Lett
; 21(21): 6582-5, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21920749
5.
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
J Immunother Cancer
; 8(2)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33243932
6.
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
J Med Chem
; 63(15): 8584-8607, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667798
7.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
J Med Chem
; 63(10): 5398-5420, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302140
8.
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo.
Mol Cancer Ther
; 19(10): 1970-1980, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788207
9.
Oxadiazolone bioisosteres of pregabalin and gabapentin.
Bioorg Med Chem Lett
; 19(1): 247-50, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19010672
10.
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
J Med Chem
; 62(13): 6190-6213, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31259550
11.
Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
J Pharmacol Exp Ther
; 327(3): 620-33, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18772321
12.
1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Bioorg Med Chem Lett
; 18(18): 5027-31, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752949
13.
Aminopyrazine CB1 receptor inverse agonists.
Bioorg Med Chem Lett
; 18(11): 3376-81, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18448340
14.
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.
Mol Cancer Ther
; 16(11): 2375-2386, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28878026
15.
Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.
J Med Chem
; 48(7): 2294-307, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801823
16.
Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.
J Med Chem
; 48(8): 3026-35, 2005 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15828841
17.
Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).
J Med Chem
; 58(24): 9480-97, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26565666
18.
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
Cancer Cell
; 28(5): 653-665, 2015 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26555175
19.
Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity.
J Med Chem
; 46(19): 4136-40, 2003 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12954065
20.
Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.
J Med Chem
; 46(4): 584-90, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570379